Process Engineer (Downstream) at Alpineimmunesciences

Are you ready to make a meaningful impact on the future of medicine? At Alpine Immune Sciences, we are a clinical-stage biopharmaceutical company dedicated to discovering and developing innovative, protein-based immunotherapies for autoimmune and inflammatory diseases. We are looking for passionate individuals to join our team and help us tackle complex scientific challenges. If you are driven by curiosity and a desire to improve patient lives, we invite you to become part of our growing community.

What you bring

We are seeking a Senior Process Engineer (Downstream) to join our CMC team on a full-time, hybrid basis. Based out of our Seattle, WA office, you will play a vital role in designing and developing downstream processes that are scalable, robust, and efficient for both clinical and commercial manufacturing. Your core responsibilities will include:

• Applying your expertise in purification operations, such as chromatography and viral filtration, to support technology transfer and the scale-up of manufacturing processes.
• Collaborating with external CDMO partners to provide technical guidance and resolve process-related issues.
• Providing essential floor support and person-in-plant oversight during development and GMP manufacturing campaigns.

Requirements

The ideal candidate is a highly motivated professional with a B.S. degree in an engineering or scientific field, though an M.S. or Ph.D. is a plus. You should bring at least four years of industry experience in purification process development, characterization, or manufacturing. Success in this role requires a deep understanding of downstream unit operations for biologics, along with familiarity with cGMP requirements, FDA guidelines, and ICH standards. You should be comfortable working with statistical design of experiments, quality by design principles, and technical documentation. We value candidates who possess excellent communication skills and the ability to thrive both independently and within a dynamic, cross-functional team environment.

What we offer

We are committed to fair compensation and offer a salary range of $100,000 to $115,000 for this position, based on experience and market data. Please note that candidates must be located in Washington state. Our comprehensive benefits package is designed to support your well-being and long-term success, including:

• Hybrid work flexibility
• Stock options
• Medical, dental, and vision insurance
• Life insurance
• 401k plan
• Paid time off

How to Apply

If you are excited about the prospect of solving complex problems in immunology and contributing to the development of life-changing therapies, we would love to hear from you. Please submit your application to join our team and help us continue our mission of innovation and scientific excellence.