Process Engineer (Downstream) at Alpineimmunesciences

At Alpine Immune Sciences, we are driven by a singular mission to discover and develop protein-based immunotherapies that change the lives of patients suffering from inflammatory and autoimmune conditions. As a clinical-stage biopharmaceutical company, we rely on our core values to navigate complex scientific challenges and push the boundaries of what is possible in immunology. We are looking for passionate individuals who thrive on collaboration and innovation to join our team in Seattle.

The role

We are seeking a Senior Process Engineer to join our CMC team on a full-time, hybrid basis. You will play a vital role in designing and developing downstream processes that are scalable, robust, and cost-effective for both clinical and commercial manufacturing. This position is based in our Seattle, WA office, and you will be expected to reside in Washington state to fulfill the requirements of this role.

Core responsibilities

• Apply your expertise in purification operations, such as chromatography, viral inactivation, and ultrafiltration, to lead technology transfers and scale-up efforts for our manufacturing processes.
• Collaborate closely with external CDMO partners to provide technical guidance, troubleshoot process issues, and ensure high-quality outcomes.
• Provide hands-on floor support and serve as a person-in-plant during development and GMP campaigns, while also performing lab-scale purification using AKTA systems.

Skills and experience

To be successful in this role, you should possess the following qualifications:

• A B.S. degree in an engineering or scientific discipline, with an M.S. or Ph.D. considered a plus.
• At least 4 years of industry experience focused on purification process development, characterization, or manufacturing.
• Deep knowledge of unit operations for biologics, including experience with cGMP requirements, FDA guidelines, and ICH standards.
• Proficiency in statistical Design of Experiments, Quality by Design principles, and the creation of technical documentation such as reports and protocols.
• Strong communication skills and the ability to work effectively both independently and within cross-functional teams.

Compensation and benefits

We are committed to fair compensation practices and offer a salary range of $100,000 to $115,000 for this position. Our comprehensive benefits package is designed to support your health, financial future, and work-life balance, including:

• Stock options to ensure you share in our collective success.
• Premium medical, dental, and vision insurance coverage for you and your dependents.
• Life insurance and 401k retirement plans.
• Generous paid time off to ensure you have the opportunity to recharge.
• A flexible hybrid work environment.

How to apply

If you are ready to contribute to groundbreaking immunotherapies and join a team that values innovation and healthy debate, we would love to hear from you. Please submit your application to be considered for this opportunity to help us advance our clinical and commercial manufacturing goals.