Principal Software Engineer Full Stack
Hybrid
Full Time
#Software Engineering
#Python
#Javascript Typescript
#Angular
#Docker
#AWS ECS
#EKS
#DynamoDB
#Postgres
At Matterworks, we are on a mission to transform the future of medicine. We build sophisticated AI tools designed to decode massive amounts of biological data, helping researchers unlock new breakthroughs in therapeutic discovery, development, and manufacturing. By creating large-scale deep learning models that predict how biological systems behave, we are changing the way science is done. We are looking for a visionary engineer to join our team and help us build the next generation of scientific software.
Role at a glance
We are searching for a Principal Software Engineer to join us in a full-time, hybrid capacity within the United States. This is a senior-level position where you will play a critical role in shaping the technical architecture of our products while working closely with our interdisciplinary team of scientists and machine learning experts.
Your impact
- Own the full development lifecycle, taking projects from initial user problems all the way to delivering tangible value.
- Partner with our cross-functional scientific teams to design and build transformative products that push the boundaries of biotechnology.
- Shape our technical direction and software architecture while mentoring others to help foster a high-performing engineering culture.
What you'll need
To succeed in this role, you should be a seasoned engineer who thrives in the fast-paced environment of an early-stage startup. We value craftsmanship and a pragmatic approach to solving complex problems.
- At least 8 years of professional experience in full-stack web development.
- Industry background in life sciences, biotechnology, or biochemistry.
- Deep technical expertise in Python, Javascript/Typescript, and Angular.
- Hands-on experience with Docker and AWS services including ECS, EKS, DynamoDB, and Postgres.
- A collaborative mindset with the ability to communicate effectively across multidisciplinary teams.
- Fluency in English.
Perks and compensation
We believe in supporting our team members both inside and outside of the office. Our benefits package includes:
- 401k with company match.
- Comprehensive dental, vision, and disability insurance.
- Life insurance coverage.
- Unlimited vacation policy.
- Flexible work location options and hybrid work arrangements.
- Commuter benefits.






